What are GLP-1 weight loss injections and why the fuss?
Unless you’ve been avoiding the headlines, you’ll have heard names like Ozempic, Wegovy and Mounjaro. These are GLP-1 receptor agonists first used for type 2 diabetes, now approved in the UK for certain people as weight loss injections. (NHS England overview)
Ozempic vs Wegovy vs Mounjaro: What’s available in the UK?
Not all GLP-1 medicines are licensed the same way. Here’s the quick lowdown:
| Medicine | Licensed use in the UK | Weight-loss availability |
| Ozempic (semaglutide) | Type 2 diabetes | ❌ Not licensed for weight loss in the UK (NHS) |
| Wegovy (semaglutide) | Weight management | ✔️ Available via NHS specialist services & privately (NICE TA875) |
| Mounjaro (tirzepatide) | Type 2 diabetes and weight management | ✔️ NICE-recommended; phased NHS rollout in progress (NICE TA1026 ; NHS England) |
A quick comparison of GLP-1 weight loss injections in the UK: Ozempic, Wegovy and Mounjaro.
How do GLP-1 injections work for weight loss?
GLP-1 medicines mimic your body’s natural GLP-1 hormone. These medicines activate the same receptors in the brain and gut that the hormone does, which helps regulate appetite and eating behaviour. By sending stronger or longer-lasting signals, they can:
- slow how quickly food leaves your stomach
- balance blood sugar levels
- make you feel fuller, sooner
Clinical studies show that people taking GLP-1 receptor agonists can lose, on average, around 10–15% of their body weight over 12–15 months. However, this weight loss often plateaus after around 52 weeks, and in many cases, weight can return if treatment is stopped. That’s why they’re not magic wands. To be used safely and effectively, NICE guidelines state they must be combined with a lower-calorie diet, more movement, and ongoing professional support.
(NICE TA875 ; NICE practical guide)
GLP-1 side effects: what to expect
Sulphur burps? Who knew they were even a thing? GLP-1 medicines are effective, but side effects come with the territory. (Gov.uk drug safety update)
Common GLP-1 side effects
- Nausea
- Diarrhoea
- Constipation
- Bloating
- Sulphur burps (unpleasant, but common)
- Stomach pain
- Indigestion/heartburn
- Excess wind
They’re not glamorous, but they’re normal - and usually improve with time. Eating smaller meals, sipping water and simpler foods can help. (NHS Inform)
Long-term considerations:
GLP-1 medications can lead to loss of muscle and bone mass due to overall weight loss. Maintaining adequate protein intake and regular resistance training can help preserve lean muscle and support bone health.
- Muscle: appetite reduction and calorie deficit can reduce lean body mass.
- Bone: Less muscle mass lowers mechanical load on bones, potentially reducing bone density.
How to protect yourself:
- Eat enough protein and consider supplements like Vitamin D, calcium, B vitamins and iron.
- Include resistance or weight training in your routine.
- Stay active throughout the day with small movements like walking or taking the stairs.
Call your GP or NHS 111 if you notice:
- severe tummy pain that won’t shift
- yellowing of the skin or eyes
- repeated vomiting or dehydration
FAQs: GLP-1 weight loss injections and side effects
Why do GLP-1 drugs cause nausea or sulphur burps?
They slow digestion. Food stays in the stomach longer, which can cause nausea and burping. (NHS Inform)
Can probiotics ease GLP-1 digestive discomfort?
They may help. Probiotics that support gut balance can reduce bloating or wind as gut health is recognised as important.
How long do GLP-1 side effects last?
Often just a few weeks, especially if doses are increased gradually. (NHS Inform)
Could I become nutrient deficient?
Yes. Appetite loss and slower digestion can reduce intake of protein, fibre, vitamins (B12, D, A, C, E, K) and minerals such as iron and magnesium. Nutrient-rich foods, or supplements, where appropriate can help BMJ review.
Why lifestyle still matters with GLP-1 jabs?
GLP-1 medicines can help - but they don’t do the heavy lifting alone. Long-term success still depends on:
- Food: protein, fibre and colourful veg - the nutrients most likely to dip when appetite is low.
- Movement: not just gyms - walks, stretching, even dancing round the kitchen all count.
- Sleep: poor rest disrupts appetite and blood sugar, so consistency matters.
NICE and the BMJ both stress professional support is essential throughout treatment. Our pharmacists can guide you with practical, personalised advice - whether that’s easing Ozempic side effects, managing fatigue, or spotting nutrient gaps.
E-mail: pharmacist@thenakedpharmacy.com
Speak to a pharmacist: 01483 678 438
Book a consultation here
Supplements and nutrients: what’s safe with GLP-1 medicines?
It’s a common question: Is it safe to take supplements with GLP-1 injections?
The answer’s yes, but not all supplements suit everyone.
- Probiotics may help with bloating or sulphur burps.
- Saffron supplements to provide emotional support.
- Vitamin D and magnesium cover common UK deficiencies. (NHS guide)
- Extra fibre can support bowel health if constipation is an issue.
Always check with a pharmacist before starting anything new.
Our pharmacist’s tip
If you’re considering GLP-1 treatment, preparation is key. Simple strategies like timing meals, staying hydrated, and monitoring nutrient intake can make a real difference in how you feel day-to-day.
Book a free chat today to discuss personalised ways to support your body safely throughout your journey.
Final word: go supported, not solo
GLP-1 medicines like Wegovy, Mounjaro and Ozempic are often glamourised on social media as a quick fix for weight loss. But the reality is that these are serious prescription medications. While they can be effective when used correctly, they also carry potential side effects such as nausea, bloating and fatigue, and they must always be taken under professional supervision.
That’s why it’s so important to do your research, follow medical guidance carefully, and understand how to support your body alongside treatment. With the right strategies – including nutrition, lifestyle changes and, where appropriate, supplements – you can help make the journey safer, smoother and more sustainable.
Speak to our expert pharmacists today
Our pharmacists are here to listen, advise and guide you so that you feel empowered, informed and supported every step of the way.
E-mail: pharmacist@thenakedpharmacy.com
Speak to a pharmacist: 01483 678 438
Book a consultation here
