Research

Bergamot



At The Naked Pharmacy, we ensure that all of our supplements are made with effective strength bioactives, so they are clinically proven to work.

We aim for each supplement to be scientifically supported by multiple randomised placebo-controlled studies. All clinical trial studies we use to support our supplements are undertaken on human patients, using the exact same dosage and formulation of the product. The scientific studies are published in peer review journals.

What can Bergamot do for you?



Research is now showing that the four specific polyphenols in high strength organic bergamot fruit extract provide effective support for managing weight and cholesterol, by binding to bad fats in the gut.

Naringin, Neohesperidin, Melitidine and Bruteridin are the primary bioactives in bergamot. We know they’re most effective at a concentration of 47% so that’s what you’ll find in our Bergatone supplement.

Research has shown that these bioactives directly block cholesterol production. They also influence the enzymes in the liver when processing fats, without causing interactions with conventional medications. Studies have shown that using Bergamot extract alongside a statin enables the statins to be effective at lower doses.

If you’d like for more information on the available evidence which details and supports the efficacy of bergamot, follow the links below.



The scientific studies to support our claims on bergamot are published in the following peer review journals:

Study: Bergamot polyphenolic fraction enhances rosuvastatin-induced effect on LDL-cholesterol, LOX-1 expression and protein kinase B phosphorylation in patients with hyperlipidemia by Gliozzi M et al, 2013

— RCT Randomised placebo controlled
— 77 Human participants

The aim of this study was to investigate the occurrence of an enhanced effect of bergamot-derived polyphenolic fraction (BPF) on rosuvastatin-induced hypolipidemic and vasoprotective response in patients with mixed hyperlipidemia.

The authors concluded that the addition of BPF to rosuvastatin significantly enhanced the effect of rosuvastatin on serum lipemic profile, compared to rosuvastatin alone. This lipid-lowering effect was associated with significant reductions of biomarkers used for detecting oxidative vascular damage, suggesting a multi-action enhanced potential for BPF in patients on statin therapy.

Study: Bergamot Reduces Plasma Lipids, Atherogenic Small Dense LDL, and Subclinical Atherosclerosis in Subjects with Moderate Hypercholesterolemia: 6 Months Prospective Study by Peter P. Toth et al, 2016

— RCT Randomised placebo controlled
— 80 Human participants

The aim of this study was to fully investigate the effects of a Bergamot extract on cardio-metabolic parameters, including plasma lipids, atherogenic lipoproteins and subclinical atherosclerosis.

The authors concluded that bergamot fruit extract supplementation significantly reduced plasma lipids and improved the lipoprotein profile. Carotid intima-media thickness (cIMT) was also reduced significantly over a relatively short time frame of 6 months.

Glossary of Terms



There are a few key terms to be aware of when reviewing these studies:

Randomised clinical trial

A clinical trial in which the participants are assigned randomly (by chance alone) to different treatments.

Double-blind study

A study in which neither the participants nor the experimenters know who is receiving a particular treatment. This procedure is utilized to prevent bias in research results. Double-blind studies are particularly useful for preventing bias due to demand characteristics or the placebo effect.

Placebo

An inactive treatment used in a clinical trial, sometimes referred to as a “sugar pill.” A placebo-controlled trial compares a new treatment with a placebo, in order to give greater confidence that the result is only due to the test/active ingredient.

P-value

The probability of obtaining the observed results of a test. The lower the p-value is, the more confident we can be of a true result. For example, a p- value of 0.001 confirms a result as 99.9% accurate.



At The Naked Pharmacy, we ensure that all of our supplements are made with effective strength bioactives, so they are clinically proven to work.

We aim for each supplement to be scientifically supported by multiple randomised placebo-controlled studies. All clinical trial studies we use to support our supplements are undertaken on human patients, using the exact same dosage and formulation of the product. The scientific studies are published in peer review journals.

What can Bergamot do for you?



Research is now showing that the four specific polyphenols in high strength organic bergamot fruit extract provide effective support for managing weight and cholesterol, by binding to bad fats in the gut.

Naringin, Neohesperidin, Melitidine and Bruteridin are the primary bioactives in bergamot. We know they’re most effective at a concentration of 47% so that’s what you’ll find in our Bergatone supplement.

Research has shown that these bioactives directly block cholesterol production. They also influence the enzymes in the liver when processing fats, without causing interactions with conventional medications. Studies have shown that using Bergamot extract alongside a statin enables the statins to be effective at lower doses.

If you’d like for more information on the available evidence which details and supports the efficacy of bergamot, follow the links below.



The scientific studies to support our claims on bergamot are published in the following peer review journals:

Study: Bergamot polyphenolic fraction enhances rosuvastatin-induced effect on LDL-cholesterol, LOX-1 expression and protein kinase B phosphorylation in patients with hyperlipidemia by Gliozzi M et al, 2013

— RCT Randomised placebo controlled
— 77 Human participants

The aim of this study was to investigate the occurrence of an enhanced effect of bergamot-derived polyphenolic fraction (BPF) on rosuvastatin-induced hypolipidemic and vasoprotective response in patients with mixed hyperlipidemia.

The authors concluded that the addition of BPF to rosuvastatin significantly enhanced the effect of rosuvastatin on serum lipemic profile, compared to rosuvastatin alone. This lipid-lowering effect was associated with significant reductions of biomarkers used for detecting oxidative vascular damage, suggesting a multi-action enhanced potential for BPF in patients on statin therapy.

Study: Bergamot Reduces Plasma Lipids, Atherogenic Small Dense LDL, and Subclinical Atherosclerosis in Subjects with Moderate Hypercholesterolemia: 6 Months Prospective Study by Peter P. Toth et al, 2016

— RCT Randomised placebo controlled
— 80 Human participants

The aim of this study was to fully investigate the effects of a Bergamot extract on cardio-metabolic parameters, including plasma lipids, atherogenic lipoproteins and subclinical atherosclerosis.

The authors concluded that bergamot fruit extract supplementation significantly reduced plasma lipids and improved the lipoprotein profile. Carotid intima-media thickness (cIMT) was also reduced significantly over a relatively short time frame of 6 months.

Glossary of Terms



There are a few key terms to be aware of when reviewing these studies:

Randomised clinical trial

A clinical trial in which the participants are assigned randomly (by chance alone) to different treatments.

Double-blind study

A study in which neither the participants nor the experimenters know who is receiving a particular treatment. This procedure is utilized to prevent bias in research results. Double-blind studies are particularly useful for preventing bias due to demand characteristics or the placebo effect.

Placebo

An inactive treatment used in a clinical trial, sometimes referred to as a “sugar pill.” A placebo-controlled trial compares a new treatment with a placebo, in order to give greater confidence that the result is only due to the test/active ingredient.

P-value

The probability of obtaining the observed results of a test. The lower the p-value is, the more confident we can be of a true result. For example, a p- value of 0.001 confirms a result as 99.9% accurate.

NEWSLETTER

Want to stay up-to-date with the latest scientific developments in natural health? We'd love to have you join us!