The Immune System Solution

Olive Leaf

Olive leaf extract has been used to treat inflammation and infection for centuries. Packed with high levels of change to the plant phytochemical Oleuropein, olive leaf is known for its immune-boosting benefits. We use pharmaceutical technology to increase the strength of the natural component ELA in order to strengthen the immune system effects of this remedy.

What Olive Leaf can do for you?

Olive Leaf helps your immune system fight off bugs and supports healthy blood pressure.

  • Supports your immune system
  • Helps protect your immune system from seasonal challenges
  • Can be taken safely alongside antibiotics
  • Provides protection against ear nose and throat infections

The Science

Olive Leaf extract is derived from the leaves of the olive tree and is rich in polyphenols, particularly oleuropein and hydroxytyrosol. These compounds exhibit potent antimicrobial, antioxidant, and cardioprotective properties. Olive Leaf supports the immune system by inhibiting viral replication and reducing inflammation, while also promoting healthy blood pressure and circulation. It is especially helpful during periods of immune vulnerability or cardiovascular stress. By combining defence with metabolic support, Olive Leaf acts as a multifaceted shield for modern immune and heart health.

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The Studies

"At The Naked Pharmacy, we ensure that all of our supplements are made with effective strength bioactives, so they are clinically proven to work.

We aim for each supplement to be scientifically supported by multiple randomised placebo-controlled studies. All clinical trial studies we use to support our supplements are undertaken on human patients, using the same dosage and formulation of the product. The scientific studies are published in peer review journals."

The scientific studies to support our claims on olive leaf and elenolic acid are published in the following peer review journals:

Study: The Metabolic Effects of Cynara Supplementation in Overweight and Obese Class I Subjects with Newly Detected Impaired Fasting Glycemia. M Rondanelli et al, 2020. Double blind randomised placebo controlled trial, 54 human participants.

What the study was about:

This study looked at whether a special extract from artichoke (called Cynarascolymus or Cs) could help people with impaired fasting glucose—a condition that often comes before diabetes—by improving blood sugar control and other related health measures.

How they did it:

54 overweight adults with newly diagnosed impaired fasting glucose were split into two groups: one took the artichoke extract and the other took a placebo (a “dummy” pill). Various health markers like blood sugar, cholesterol, insulin levels, waist size, and body fat were measured over time.

What they found:

The group taking the artichoke extract showed significant improvements in blood sugar levels, cholesterol (good and bad), insulin, and body fat around the belly compared to the placebo group.

What it means:

Taking this standardised artichoke extract might help people at risk of diabetes improve their blood sugar and other metabolic health factors.

 

Study: Efficacy of artichoke leaf extract in non-alcoholic fatty liver disease. Y Panahi et al, 2018. Double blind randomised placebo controlled trial, 100 human participants.

What the study was about:

Non-alcoholic fatty liver disease (NAFLD) is a common liver condition that can get worse over time, but treatment options are limited. This study looked at whether artichoke leaf extract (ALE) could help improve liver health in people with NAFLD.

How they did it:

100 people with NAFLD were randomly given either ALE or a placebo every day for 2 months. Doctors checked their liver health using ultrasound scans and blood tests both before and after the treatment.

What they found:

Those who took ALE showed improvements in liver blood flow, smaller liver size, and better liver blood test results. They also had lower cholesterol and triglyceride levels compared to those taking the placebo. Importantly, no side effects were reported.

What it means:

Artichoke leaf extract might be a safe and helpful way to improve liver health and cholesterol levels in people with fatty liver disease.

Study: Artichoke leaf extract (Cynara scolymus) reduces plasma cholesterol in otherwise healthy hypercholesterolemic adults. R. Bundy et al, 2008. Double blind randomised placebo controlled trial, 75 human participants. 

What the study was about:

Heart disease is a leading cause of death, often linked to high cholesterol levels. This study tested whether artichoke leaf extract (ALE) could help lower cholesterol in healthy adults with mildly to moderately high cholesterol.

How they did it:

75 adults with total cholesterol between 6.0 and 8.0 mmol/l took either 1280 mg of ALE or a placebo every day for 12 weeks. Their cholesterol levels and general well-being were checked before and after.

What they found:

The group taking ALE had their total cholesterol drop by about 4.2%, while the placebo group’s cholesterol slightly increased. This difference was statistically significant, meaning it was likely due to ALE. However, there were no significant changes in the “bad” (LDL) or “good” (HDL) cholesterol or triglycerides. Both groups reported similar improvements in general well-being.

What it means:

Taking artichoke leaf extract can modestly but significantly lower total cholesterol in people with mild to moderate high cholesterol. The overall good health of the participants might explain why the effect was modest.

Glossary of terms:

There are a few key terms to be aware of when reviewing these studies:

Randomised Clinical Trial

A clinical trial in which the participants are assigned randomly (by chance alone) to different treatments.

Double-blind study

A study in which neither the participants nor the experimenters know who is receiving a particular treatment. This procedure is utilised to prevent bias in research results.

Double-blind studies are particularly useful for preventing bias due to demand characteristics or the placebo effect.

P-value

The probability of obtaining the observed results of a test. The lower the p-value is, the more confident we can be of a true result. For example, a p- value of 0.001 confirms a result as 99.9% accurate.

Placebo

An inactive treatment used in a clinical trial, sometimes referred to as a “sugar pill”.

A placebo-controlled trial compares a new treatment with a placebo, in order to give greater confidence that the result is only due to the test/active ingredient.